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Certain brain structures in trans women have been found to be similar to cisgender women's as opposed to cis men's, and trans men's have been found to be similar to cis men's, even controlling for hormone use , which can also cause trans people's brains to become closer to those of cis people of the same gender. The hyphenation signals a crisis of language and an apparent social contradiction, since sex and gender are 'supposed' to match. Individuals who have undergone and completed sex reassignment surgery are sometimes referred to as transsexed individuals;  however, the term transsexed is not to be confused with the term transsexual, which can also refer to individuals who have not yet undergone SRS, and whose anatomical sex still does not match their psychological sense of personal gender identity.
The previous version, ICD, had incorporated transsexualism, dual role transvestism, and gender identity disorder of childhood into its gender identity disorder category. Male-to-female transsexualism has sometimes been called "Harry Benjamin's syndrome" after the endocrinologist who pioneered the study of dysphoria.
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The differences between transgender and transsexual and intersex have been understood by lawmakers in countries such as Australia where lawmakers have publicly acknowledged that people with intersex conditions have distinct needs from people who identify as transgender or transsexual.
Likewise, studies such as Rametti's have found that trans men have male-like white matter patterns even before using hormones , regardless of sexual orientation. Like other trans people, transsexual people prefer to be referred to by the gender pronouns and terms associated with their gender identity.