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These data further support a favourable safety profile of GH therapy in patients with NS, specifically the absence of any cardiac AEs. Distribution is shown as percentage of patients in each age group in the relevant period.
Nevertheless, these findings emphasize the need for accurate growth monitoring during the healthcare maintenance of all children, particularly girls, to ensure appropriate referral and treatment. Distribution of short children born SGA by GH treatment start period —, — or — and age group.
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Aside from the evidence that age at treatment start is inversely associated with the response to therapy, starting GH replacement early also allows a longer duration of treatment and therefore more time for catch-up growth before children reach puberty, with the potential for better outcomes [ 29 ]. From to the observed mean age at treatment start decreased from